Showing posts with label Health-Diabetes. Show all posts
Showing posts with label Health-Diabetes. Show all posts

Could Available Drugs Regenerate beta Cells? – Part 2 - Diabetes 28

Thursday, January 6, 2022

You may read previous posting (Part 1):

- Could Available Drugs Regenerate beta Cells? – Part 1 - Diabetes 28


Fig 01- Some drugs at pharmacy store


In addition to treat diabetes, GLP-1 receptor agonists (GLP-1 Ras) have other several advantages:

- heart health

- and kidney function


Researchers from Icahn medical school, Mount Sinai, New York combined both DYRK1A inhibitors and GLP-1 receptor agonists to see their effect on beta cell replication on human with diabetes.


The result is quite surprising!


Fig 02- A nice pet


Fig 03- Mermaid tail, illustration.


Finding of research may be summarized as following:

1) It is possible to replicate beta cells in diabetes patients

- previous research was fail.


2) Combine drugs able to produce beta cells in quite numbers

- about 5% to 6% after four days treatment.

- while using GLP-1 receptor agonist alone produce 2% beta cells only


3) Further developments

- Scientists believe that combines with other inhibitor drugs could increase cells replications significantly.


# Previous postings:

- What Effect of Diversity Patrons on the Arts in the 15th-18th centuries? - part 1

- Is it Norm to Hire Underage Workers in Developing Countries? - part 1

- Is Aarhus, Denmark the Happiest City in the World?

- Hurricane Barry Made Landfall in Louisiana Recently

Could Available Drugs Regenerate beta Cells? – Part 1 - Diabetes 28

Friday, December 24, 2021

We have talked about dangerous of several drugs in the market that cause negative effect on beta cells to produce insulin:

- Why Pancreas of Type 2 Diabetic Persons Produce Less Insulin? - Diabetes 3

- Could Medicines Affect on Pancreas to Produce Insulin? - Diabetes 4


Fig 01- Diet for diabetes


However, based on research published in Science Translational Medicine, Vol.12, no 530 (February, 2020) that two type of drugs are able to grow beta cells in human pancreas.


Two type of drugs which could replicate beta cells are:

- DYRK1A inhibitors

- and GLP-1 receptor agonists


Researchers found that using DYRK1A inhibitors alone could stimulate beta cells productions, but at modest level only.


Fig 02- Illustration purpose


Fig 03- Sagitarius, Illustration only


Then researchers searched other possibility by using GLP-1 receptor agonists which are prescription drugs to treat diabetes.


Some of GLP-1 receptor agonists are following:

- Novo Nordisk’s Victoza

- Ozempic

- Rybelsus

- Eli Lilly’s Trulicity

- and AstraZeneca’s Bydureon.


# To be continued to Part 2


# Previous postings:

- Who are the stars of Renaissance Artists? - Part 1

- Do You Like Paper Map Instead of Digital One?

- Why Neon Tetra Fish is Good For Aquarium?

- Have You Ever Tasted a Super Hot of Habanero Pepper?

- Are Thermopolia the First Fast Food Restaurant?

What Habit may Contribute to Diabetes? - Diabetes 27

Monday, November 8, 2021

This post is summary of several readings, include:

- Lipla Nagi, 2015. Six bad habits that put you at risk for diabetes.

- Donna SM, et al, 2014. Behavioral Contributions to the Pathogenesis of Type 2 Diabetes.


Magnolia flowers in the last spring


There are some habits could caused diabetes, they are:

1) Stay until late night (until morning) leads to development of diabetes.

- The 8 hours sleep will not set off development.

- However, late night disrupts sleep quality that lead to bad metabolism, then affect to blood sugar regulation.


2. Using of plastic wrap may cause insulin resistance:

- thus increased risk of diabetes, especially for children.


3.Avoid sun in longer period may increase risk of diabetes.

- It is because lack of sun lead to vitamin D deficiency, then decrease pancreases ability to produce insulin.


Falling tree, just for illustration


4.Too much sitting may increase risk of diabetes.

- One hour sitting will increase risk by 4%.

- Sitting may cause storage of visceral fat, thus reduce insulin sensibility.


5.Skip breakfast may cause hungry at late morning, thus increase risk of type 2 diabetes.


# Previous postings:

- What are Significant of Statues on Easter Island?

- What Kinds of Spring Wild Flowers in Your Backyard?

- Why do People Want to Go to College?

- Is Bitter Melon Good for Health?

- What is Painting Stylistic of Rococo?

- Can a Storage be Remodeled as a Nice Home?

- When is the Proper Time to Cut Trees Down?


A Low Carbohydrate Food – Diabetes 26

Thursday, September 16, 2021

Fried rice with low calories


Many grains in the commercial markets are considered as high calories diet. These grains include:

- rice
- wheat
- oats


As suggested by Butler, N (MedicalNewsToday, 2018) that American should consume 2,000 to 2,500 calories per day.


About 1,100 calories must come from carbs which equal to 275 gram carbohydrates per day.


However, diabetes patients should eat much lower calories contents of foods, it is about 1,200 to 1,600 calories per day.


Since rice is one of higher calories foods, and should be avoided or limited, hence, unfortunate for many million of diabetic people around the globe, especially diabetic patients from Asian countries who eat rice as main source of energy.


Wild fruit, illustration only.


Sure, food intake management could be done to make blood sugar level under control.


Bird Eye is a brand well known for freezing foods in the package. The brand is own by several companies now:

- Conagra Brands (United States)
- Nomad Foods (Europe)
- Simplot (Australia)


The brand then develop called a “cauliflower rice” which contain:

- low carbohydrates
- high fiber
- antioxidants
- vitamins


Its may be alternative to real rice, and good for diabetic people.


# Previous postings:

Can Insulin be Produced from Laboratory Dish? - Diabetes 25

Saturday, August 15, 2020

 

Illustration purpose only


We have talked about role of pancreatic beta cells to produce insulin. These are examples of posts relate to beta cells:


Why Pancreas of Type 2 Diabetic Persons Produce Less Insulin? - Diabetes 3 | Tanza Erlambang Update

Could Medicines Affect on Pancreas to Produce Insulin? - Diabetes 4 | Tanza Erlambang Update

How to Activate Damaged Beta Cell in Pancreas to Produce Insulin? - Diabetes 21 | Tanza Erlambang Update


Recently, researchers have tried to develop beta cells from human stem cells in a dish. It is expected that these beta cells will secrete insulin in response to a given glucose.


First attempted was failed, it is because stem cells interrupted to grow to be pancreas beta cells in the let’s say Petri dish.


Succulent plants in the pot, just for illustration


Scientists knew that specific receptor protein called estrogen related receptor γ (ERRγ) abundant in beta cells. Then scientists injected this receptor protein to improve process of cells maturation in the lab.



Surprisingly, the mature beta cells produce insulin in the Petri dish. For further test, then, the beta cells are transplanted into mice (diabetic mice).


The result is promising that beta cells secrete insulin to respond the high blood sugar level in the mice.


The next steps to find out:

- how to transplant the Petri dish’s beta cells into human being

- can beta cells be function to produce insulin to control sugar level in human?


At least, we see light to help diabetes patients, especially type 1 diabetic patients where their pancreas stop to produce insulin at all.


We are waiting the great finding to treat diabetes in the near future!

Tea for Diabetes Patients – Diabetes 24

Saturday, July 11, 2020
Tea bag of diabetes tea.

We talked about advantage of green tea to control blood sugar level (please read: Could Green Tea Improve Insulin Sensitivity? - Diabetes 11 | Tanza Erlambang Update).

Actually, there are many teas that good for diabetes, some of them are:
- Hibiscus tea
- Ginger tea
- Black tea
- Bitter Melon tea
- Bigelow green tea
- Chamomile tea
- Cinamon tea


Tea for diabetes, ready for drink.


I just take picture this kind of diabetes tea in the ethnic grocery. It is said that the tea is herbal supplement, contains “polyphenols.”

Substance called polyphenols which may combines of:
- flavonoids
- theaflavins
- tannins
- catechins

Polyphenols is antioxidant used to improve insulin sensitivity, thus manage or prevent diabetes type 2.

Drinking tea is getting popular in America lately. American drink 155 cups of tea per year. They consume mainly black tea. Some drinks green tea.

It is suggested that people drink at least 4 cup of teas may reduce their risk get diabetes about 30% to 33%.

Have you drink tea? How many cups per day?

# Previous posts:



Effect of Drink Chia Seeds for Diabetes Patients – Diabetes 23

Thursday, April 30, 2020
Chia seed in a glass of water

Some friends told me that Chia seed is good for health. The seeds are from plant includes in mint family.

Two species of plants, Salvia hispanica and Salvia columbariae could be found in the areas of:
- the southwestern United States
- Mexico
- Central America

Chia seeds are quite small, 1 mm in diameter with color tend to dark gray. We found white and black spots on these oval seeds.

We may consume seed with water. 10 gram of Chia seed is good enough for one glass of water. Some flavors such as orange, mango and lime may be added to the drink.

In term of diabetes, seeds are believed to benefit for type 2 diabetes patients. Few studies have shown that Chia seeds:

- improve insulin sensitivity
- control blood sugar
- lower blood sugar level after eating foods.

Do you know Chia seeds? Have you consume it?

Other posts relate to diabetes:



The Roles of Incretin Hormones for Diabetes Patients - Diabetes 22

Friday, April 3, 2020
Fig 01- Incretin hormone in the body (credit to Wiley Online Library)

We just mentioned little bit about Incretin Hormones in the previou post, How Lipotoxicity Relate to Diabetes? - Diabetes 6 | Tanza Erlambang Update

This hormone is created to trigger our body to respond to food intake. Our body has two kind of Incretin Hormones:
- GLP 1 (Glucagon Like Peptide 1)
- GIP (Gastric Inhibitory Peptide)

When we are eating foods, our gut produce GLP 1 to stimulate beta cells in pancreas to produce insulin and our body to decrease appetite.

In case of appetite decreasing, there is involvement of the mechanisms of brain – gut responses. The responses include by increasing of energy expenditure.

Scientists may exploit this mechanism by designing specific drugs and foods to treat metabolic diseases and over weight people.

Other roles of GLP 1:
- influence gut motility
- inhibit secretion of gastric acid
- inhibit secretion of glucagon.


Fig 02- Bell peppers. Spicy vegetable


Fig 03- Cheese in the grocery. Illustration

In respect to diabetes, GLP 1 has several functions:
- inhibit releasing of post-prandial glucagon
- slow down the stomach emptying
- the most important is increasing insulin sensitivity.

We will discuss little bit about GIP (Gastric Inhibitory Peptide) by next post.

Other diabetes relate posts: