As we might know that messenger ribonucleuc acid (mRNA) play crucial role to supply information to DNA in protein synthesis to regulate cells and tissues in our body.
Unfortunately, virus, in this case Covid-19 “manipulate” RNA to enable to enter cells, then duplicate itself. Consequence of this activity:
- infected people to be sick or dead
- if virus infected lung, then patient to be difficult to breath.
Vaccine is one of effective methods to control virus. Traditionally, vaccine was made by weaken or killed virus, then injected into body to stimulate immune system to produce antibody.
The traditional method has taken long time (could be years and even a decade) to develop, because of:
- make sure that weaken or dead virus be able to stimulate immune system to produce antibody
- we must certain that virus is dead or weak, not strong enough to infect human.
- search suitable media for virus to well growing
- need large scale to test effectiveness and safety of vaccine.
In 1990, scientist develop mRNA vaccine which contain viral protein. This viral protein could trick immune system to “think” that body is attacked by real virus. Then, immune system responses by producing antibody to fight virus.
In case of Covid-19, the technique is quite advance where:
- additional certain substance into mRNA to reduce negative effects of vaccine such as inflammation.
- using spike protein, a kind of protein for virus to enter cells. Thus, antibody result from vaccine to be effective to combat Covid-19.
The mRNA vaccine shown good result in first and second clinical trials, hope, will be the best result in the final trial.